Activation of autophagy through modulation of 5′-AMP-activated protein kinase protects pancreatic β-cells from high glucose

Diana HAN*, Byungho YANG*, L. Karl OLSON†, Alexander GREENSTEIN*, Seung-Hoon BAEK‡, Kate J. CLAYCOMBE*, John L. GOUDREAU‡§‖, Seong-Woon YU‡§ and Eun-Kyoung KIM*‡1 *Department of Food Science and Human Nutrition, Michigan State University, East Lansing, MI 48824, U.S.A., †Department of Physiology, Michigan State University, East Lansing, MI 48824, U.S.A., ‡Department of Neurology and Ophthalmology, Michigan State University, East Lansing, MI 48824, U.S.A., §Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824, U.S.A., and ‖Neuroscience Program, Michigan State University, East Lansing, MI 48824, U.S.A.